The root cause of premature skin ageing is excessive cellular inflammation which upsets the natural and delicate balance of our skin’s immune system. We all suffer from cellular inflammation, particularly as we age and it is associated with factors such as lack of sleep, hormones, emotional stress, as well as excessive sunlight, harsh weather conditions, air pollutants and cigarette smoke.
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While being a vital defence mechanism, excessive inflammation has been proven to cause premature ageing and occurs as a result of internal mechanisms such as the by-products of cellular metabolism and external factors such as high levels of UV radiation. Inflammation is characterised by a number of events which occur including increased blood flow, migration of immune cells, and release of free radicals and damage to normal tissue. Aurelia Probiotic Skincare helps to manage the level of inflammation within the skin, the main cause of ageing.
The body uses molecules called cytokines to naturally regulate inflammatory responses. Cytokines are a group of molecules that work within the skin's defence system and are important for cell communication. They are released by some cells and affect the behaviour of other cells. They are particularly important in health and disease, specifically in responses to infection, trauma and inflammation.
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It is important for these immune responses to be regulated, ensuring the skin isn't in a persistent state of inflammation, which can create an environment that accelerates the ageing process. Today's stressful lifestyles, alongside UV damage and external aggressors, facilitate this cycle of inflammation. Cytokines stimulate or inhibit cellular activities and play a key role in helping to control the inflammatory process and the repair of damaged skin. When the skin is not inflamed and is in a balanced and protected state DNA repair is optimised. For example, cytokine Interleukin 10 (IL10) would signal to white blood cells creating an immune response once inflammation is detected. This response is then regulated back and forth to stimulate or suppress the inflammatory response when required – achieving moderation and therefore the perfect balance.
The rate and stage at which we age depends on a number of factors including genetics, lifestyle, exposure to UV light and exposure to environmental stressors and internal factors such as stress and hormones. However, first signs of ageing usually occur in our mid to late 20s or early 30s, with fine lines appearing, pigmentation, a change in skin texture and loss of skin radiance resulting in dullness. Aurelia Probiotic Skincare's Age Prevention range has been specifically designed to target these early skin changes and continues to help manage the levels of inflammation within the skin as we age.
When skin is under stress and inflammation occurs, the extracellular matrix’s (ECM) function deteriorates. The ECM is essential for processes like growth and skin healing. When the skin becomes inflamed at the cell layer, degradation of the ECM occurs and it can no longer maintain the skin’s firm and elastic structure, leading to premature ageing.
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The ECM is the non-cellular component present within all tissues and organs and it has many important functions: it surrounds and supports cells, influences cell shape and movement and regulates cellular functions through signalling. It consists of fibres (e.g. collagen and elastin), proteoglycans and polysaccharides (e.g. hyaluronic acid) which provide a voluminous hydrated matrix and adhesive glycoproteins (e.g. fibronectin) which connect cells with fibres.
As we become older one of the main indications of ageing is when our skin starts to lose its natural glow and begins to look dull and tired. When young, our body’s renewal processes behave optimally and our skin cells turn over on average every 28 days. As we age the body’s natural ability for cell renewal deteriorates. Although the rest of our body may feel energised, the blood flow to our skin and the body’s natural replenishment process slows down and the skin’s natural enzymes that help remove and replace dead cells become inefficient. This can lead to dead skin cells piling up, which absorb light and cause our skin to appear dull and fatigued.
Dullness is a major ageing skincare concern and one we focus on greatly improving at Aurelia Probiotic Skincare.
Smooth, plump skin relies on proteins called collagen and elastin. When these two proteins are compromised, wrinkles become visible. Collagen, together with elastin, is responsible for skin strength and elasticity and these proteins give skin its youthful, supple and toned appearance. Collagen strands within the Extracellular Matrix (ECM) help to hold the skin’s structure together and form the framework of tissues. As we age, and degradation occurs, these collagen strands slacken and can break, which causes the skin to sag and wrinkles to form.
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Damage caused by inflammation and free radical formation also triggers the release of collagen- and elastin-digesting enzymes, which cause their degradation, a key factor in the loss of skin tone, skin sagging and wrinkles. In particular, fine lines and wrinkles around the eyes are also explained by the reduced effectiveness of the proteasomes within our skin cells. Proteasomes are found within our cells and their role is to destroy other proteins. They are involved in many essential cellular functions, such as regulation of the cell cycle, signalling and processing for appropriate immune responses and inflammatory responses - it is complicated and multifaceted. Strengthening the proteasome improves the natural recycling process in skin cells which helps to delay skin ageing. As we get older our proteasomes becomes less effective and this leads to the formation of fine lines and wrinkles. These often begin around the eyes and mouth.
With age, our skin becomes more prone to the development of pigment spots, a hallmark of photo-exposed skin.
Normally appearing on our face neck and hands, these clusters of excess pigment (melanin) are typically the combined result of prolonged sun exposure and high levels of stress in our skin cells.
This is because prolonged UV exposure and intense stress in our skin cells can trigger biological pathways that lead to overproduction of melanin in clusters of cells. This excess melanin is transported from melanin producing skin cells to cells in upper layers of the skin, where the dark brown spots form.
The knock on effect of this damage to the skin can also trigger the release of collagen and elastin-digesting enzymes. Collagen and elastin are important proteins which are responsible for skin strength and elasticity. They give skin its youthful supple and toned appearance and their degradation (caused by the harmful enzymes) leads to loss of skin tone, skin sagging and wrinkles.
Free radicals can cause damage to healthy cells by a process called oxidative stress which occurs in the following way:
Creates unstable molecules
Free radicals are molecules that have lost an electron which leaves them ‘incomplete’ and less stable. The free radical wants to replace its missing electron to become ‘complete’ again and is therefore more reactive than when it had all of its electrons.
Steals a healthy cell’s electrons
One way for the free radical to gain an electron and become ‘complete’ again is to react with a healthy cell molecule and ‘steal’ one of its electrons. This re-balancing process however damages the healthy cell molecule - losing one of its electrons can affect its function. When the healthy cell is attacked by the free radical and has one of its electrons stolen it then becomes a free radical itself.
Cellular DNA becomes damaged
The cell is now an unstable free radical and attempts to steal an electron from another neighbouring ‘complete’ and healthy cell. This causes a chain reaction to start in which many healthy cells may have their electrons ‘stolen’ from free radicals. The free radicals may react with important cellular components such as DNA or the cell membrane and cause irreparable damage to the cell or cause the cell to die. This contributes significantly to the ageing process as once the process has started, it can cascade, resulting in oxidative stress, damage to the skin structure and excessive levels inflammation within our skin.
A healthy antioxidant rich diet, using sun protection, relaxing more, limiting stress and drinking lots of water is a start. Using great skincare helps too! Aurelia Probiotic Technology works to harness this free radical damage, oxidative stress and systematic inflammation by using antioxidants throughout its products - this is the first fundamental step towards helping to fight ageing.
Antioxidants are naturally found in abundance in plants and fruit. Using antioxidant rich skincare is a great way to treat your skin and is the first step in helping to prevent ageing.
Antioxidants are substances which can prevent or slow cell damage in the following way:
Stabilise Cells Preventing Cell Damage An antioxidant gives one of its own electrons to an ‘incomplete’ and unstable free radical who is missing an electron. By receiving an electron from an antioxidant and becoming ‘complete’ again, the free radical does not need to steal one from a healthy neighbouring cell, resulting in the prevention of cell damage.
Thousands of natural antioxidants are found in fruit, vegetables and plants and include vitamins A, C, and E. Aurelia Probiotic Skincare is abundant in natural antioxidants from the precious BioOrganic botanicals used throughout the range that are ethically sourced from around the world. The high antioxidant content combats free radicals which are the cause oxidative stress, damage to the skin structure and, at excessive levels, induce an inflammatory response. They terminate chain reactions by removing free radical intermediates and inhibit other oxidation reactions. They do this by being oxidised themselves, working to reduce free radicals and prevent skin ageing.
Aurelia Probiotic Skincare has been all over the world and searched for the very best BioOrganic botanicals which are rich in antioxidants to add to our scientifically developed formulations. Antioxidants are fantastic when dealing with the first signs of skin ageing and paired with our three technologies offer revolutionary, next generation age prevention.
To learn more about our antioxidant rich BioOrganic botanicals, read the A-Z of ingredients and watch our botanical research film made in Malawi.